Description
Each AddPhos sachet contains 3.2 g of Sodium Acid Phosphate Granules. The sodium and potassium content in each tablet is 20.4 mmol and 3.1 mm respectively.
Pharmacology
PharmacodynamicsRenuris is available as 10.16 gm of Whey Protein in 16 gram fine powder in a sachet. 10 sachets are contained in 1 box. Sachets are specialized with three layers to keep the content of the supplement intact.
Phosphorous is one of the most abundant elements in the human body — nearly 85% is present in the skeleton, with a balance in soft tissues and extracellular fluid. Most phosphorous are complexed as phosphate which is the body’s major intercellular anion and an essential component of cell membrane phospholipids, DNA and RNA. It is also critical to most biochemical processes including ATP synthesis and metabolic and enzymatic pathways. Phosphorous, as phosphate, also assists in maintaining normal physiological pH balance.
Phosphorous balance is regulated by several hormones including Parathyroid Hormone (PTH), which controls the release of phosphate from bones and inhibits renal reabsorption. Serum phosphate levels are inversely proportional to serum calcium levels and their physiological requirements are the same.
Mechanism of Action
Oral administration of inorganic phosphates produce a fall in serum calcium in patients with hypercalcemia. The sodium ions in AddPhos granules aid in the correction of the dehydration and sodium depletion, which is seen in hypercalcemia. In cases of hypercalcemia associated with impaired renal function and hypophosphatemia, the main effect of oral phosphate is to bind calcium in the gut and thus reduce calcium absorption.
Pharmacokinetics
Absorption & Distribution
Phosphates are mainly absorbed from the jejunum and duodenum by passive and active transport. Approximately two-thirds of ingested phosphate is absorbed from the gastrointestinal tract and most absorbed phosphate is filtered by the glomeruli and subsequently undergoes reabsorption. PTH and Vitamin D stimulate absorption of phosphate from the small intestine and its reabsorption from the proximal tubule.
Metabolism & Excretion
Virtually, all absorbed phosphates are excreted in the urine; the remainder being excreted in the faeces.
Indications