Abnormal renal metabolism, inadequate intake and/or gastrointestinal absorption and dialysis losses, account for vitamin deficiencies amongst dialysis patients. Losses are even greater with high-flux and high-efficiency dialysis. Vitamin deficiency progresses slowly depending on body stores, nutritional intake and chronic dialysis losses. Vitamin status in individual patients depends on age, gender, actual vitamin intake, previous supplementation, dialysis losses, residual renal function, time on dialysis and types of dialysers in addition to impaired metabolism. Ideally vitamin supplements should be tailored to individual needs. Overt clinical manifestations include depressed immune system, neuropathy and impaired amino acid and lipid metabolism, mild scurvy and other abnormalities.
The most frequently observed vitamin disturbances concern water soluble vitamins and these may be supplemented daily or administered after dialysis.
Nefita combines all essential vitamins in required daily dose including Methylcobalamin which is the USP of Nefita. All the vitamins in Nefita on the basis of daily requirement which makes it complete and truly 1 a day.
Composition
| Ascorbic Acid |
60 mg |
| Biotin |
300 mcg |
| Folic Acid |
10 mg |
| Methylcobalamin |
1500 mg |
| Niacinamide |
20 mg |
| Pantothenic Acid |
10 mg |
| Pyridoxine |
20 mg |
| Riboflavin |
3 mg |
| Thiamine |
2 mg |
Additionally Nefita is Soft Gelatin Capsule which is the best oral delivery system because Soft gelatin capsules are a unique drug delivery system that can provide distinct advantages over traditional dosage forms such as tablets, hard gelatin capsules and liquids. Softgel is a hermetically sealed, one-piece capsule with a liquid or semisolid fill. The Softgel consists of two major components, the gelatin shell and the fill. In the finished product gelatin shell is primarily composed of gelatin, plasticizer and water.
The Softgel capsule offers the following advantages over other oral delivery systems, such as hard-shell capsules/Tablets.
- Unitary one piece dosage
- Sealed tightly in automatic manner.
- Easy to swallow.
- Allow uniformity, precision and accuracy between dosages.
- Safe against adulteration.
- Better stability than other oral delivery systems.
- Good availability and rapid absorption.
- Rely on preference of the consumer, due to their security, appearance and functionality.
- Offer protection against contamination, light and oxidation.
- Unpleasant flavors are avoided due to content encapsulation.
- The filling reproducibility is 1 to 2.5% relying on the asset to fill.
- Are elegant, and attractive as a finished product.
To summarize Nefita provides all essential vitamins in proportion to daily requirement including Methylcobalamin as Softcaps which is indeed the unique drug delivery system that can provide distinct advantages over traditional dosage forms at an irresistible price.
Side Effects
When taken as directed, multivitamins are not expected to cause serious side effects. Less serious side effects may include:
- upset stomach
- headache; or
- unusual or unpleasant taste in your mouth
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.
Precautions
Folic acid may mask the symptoms of pernicious anemia in that hematological remission may occur while neurological manifestations remain progressive.
Dosage and Administration
One capsule daily or as directed by a physician. If on dialysis, take after treatment. Use this medication as directed on the label, or as your doctor has prescribed. Do not use the medication in larger amounts or for longer than recommended.
Never take more than the recommended dose of a multivitamin. Avoid taking more than one multivitamin product at the same time unless your doctor tells you to. Taking similar vitamin products together can result in a vitamin overdose or serious side effects.
Avoid the regular use of salt substitutes in your diet if your multivitamin contains potassium. If you are on a low-salt diet, ask your doctor before taking a vitamin or mineral supplement.
Do not take this medication with milk, other dairy products, calcium supplements, or antacids that contain calcium. Calcium may make it harder for your body to absorb certain ingredients of the multivitamin.
It is important to take multivitamins regularly to get the most benefit.
Overdose
Overdose symptoms may include stomach pain, vomiting, diarrhea, constipation, loss of appetite, hair loss, peeling skin, tingly feeling in or around your mouth, changes in menstrual periods, weight loss, severe headache, muscle or joint pain, severe back pain, blood in your urine, pale skin, and easy bruising or bleeding.
Storage
Store Nefita at room temperature away from moisture and heat.
Presentation
Nefita is available as soft gelatin capsules in a blister of 5 capsules and 10 such blisters in a box
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